Early hypercapnia and cerebrovascular autoregulation. Shows the time with impaired cerebrovascular autoregulation (CVA; in % of the total monitoring time) in ARDS patients with early hypercapnia vs. no early hypercapnia. The COx was depicted as a moving linear correlation based on mean arterial pressure and cerebral oxygenation (ICM+, Cambridge Enterprise, Cambridge, UK). Impaired cerebrovascular autoregulation was defined as a COx > 0.3. ARDS Acute respiratory distress syndrome, COx cerebral oxygenation index. Data are presented as median (boxes) with Tukey whiskers